Fluoride and lead are two common pollutants in the environment. Previous investigations have found that high fluoride exposure can increase the lead burden.
Exposure to environmental pollutants and drugs can result in pathophysiological situations in the body. Research in this area is essential as the knowledge on cellular survival and death would help in designing effective therapeutic strategies that are needed for the maintenance of the normal physiological functions of the body.
"... prospective studies of children's cohorts that applied sensitive neurobehavioral methods supported the notion that the brain is uniquely vulnerable to toxic damage during early development. Lead, methylmercury, and arsenic thereby serve as paradigm neurotoxicants that provide a reference for other substances that may have similar adverse effects. Less evidence is available on manganese, fluoride, and cadmium, but experience from the former trace elements suggest that, with time, adverse effects are likely to be documented at exposures previously thought to be low and safe."
Biol Trace Elem Res. 2015 Mar;164(1):99-105. doi: 10.1007/s12011-014-0205-3. Epub 2014 Dec 23.
PMID:25529766 Proteome alterations in cortex of mice exposed to fluoride and lead.
2014 Dec;162(1-3):227-33. doi: 10.1007/s12011-014-0117-2. Epub 2014 Sep 27.
PMID:25260320 Proteomic analysis of hippocampus in offspring male mice exposed to fluoride and lead.
Food Chem Toxicol. 2013 Dec;62:584-600. doi: 10.1016/j.fct.2013.09.026. Epub 2013 Sep 29.
PMID: 24084033 An update on oxidative stress-mediated organ pathophysiology.
J Trace Elem Med Biol. 2015;31:130-4. doi: 10.1016/j.jtemb.2014.07.023. Epub 2014 Aug 9.
PMID:25175507 Trace elements as paradigms of developmental neurotoxicants: Lead, methylmercury and arsenic.
At the time of this writing I have not verified if in fact the fluoridating of Flint water has been halted or not. Recommendations to cease the fluoridation practice were made back at least as far as early 2015. http://www.mlive.com/news/flint/index.ssf/2015/02/erin_brockovich_water_expert_s.html